iAvoe I've also downloaded 5RC2 now to test your presets. High Quality, High Compression would run like 24 hrs for a 30min video? Is that normal? I'm on Ryzen 3700X and GTX 1070.
And the more interesting thing is that the high quality preset always fails. The lossless (fast) preset as well. Adobe Media Encoder logs this:
Es war nicht möglich den Encoder zu initialisieren.
Dieser Fehler tritt meinstens bei einer ungültigen Parameterkonfiguration auf.
Which means that this parameterconfig isn't valid.
Did you tried this one Vouk ?